| Identification |
|---|
| BMDB Protein ID
| BMDBP00404 |
| Secondary Accession Numbers
| None |
| Name
| tRNA (guanine(37)-N1)-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| TRMT5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in tRNA (guanine-N1-)-methyltransferase activity |
| Specific Function
| Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| TRMT5 |
| Gene Sequence
|
>1494 bp
ATGAGGAGCTTATTGAAACAATTTGCATTCTCAAGAAGACTTCTCAAAGTGGAAAGCTGT
AGAATAACTGAGTCAGCATCACTGATTCTACTACCTTGGGCATCGTTGATACAGAAGCTT
AACAGAGTACCTGTTATTTTCTTGCTGGATCAAAGAAAAAGATTCTCAACCATGCCTGAA
ATAGAAACAAATCACAGAGACTCTGAATTGTTTTCCCCACCCTCTGAAGTTCGAGGAATG
ACAGAACTTGATAGAACAGCTTTTAAAAAGACAGTCACCATCCCAGTGCTTAAAGTGAGG
AAAGAAGTAGTCAATAAACTGATGCGATCCCTTAAAAGAGCAGCACTGCAGCGCCCAGGC
ATAAAACGTGTGATTGAAGATCCAGAAGATGGAGAAGGTAGACTAATTATGTTGGATCCC
TATAAAATGTTTACTGTTGACTCCTTTGAGAAAGAAGAACTCAGTATTTTAAAGCAGCTG
AATGTCAATCCACAGATATCGAAATATAATTTGGACCTAACTTATGAAAACTTTAAGTCA
GAAGAAATCTTGAGAGCTGTGCTTCCTGAAGGTCAAGATGTGACCTCAGGGTTTAGCAGA
GTTGGACACATTGCTCACCTGAACCTTCGAGATCATCAACTACCTTACAAGCATTTAATT
GGCCAAGTTATGATTGACAAAAATCCAGGAATCACCTCAGCAGTAAATAAAATCAATAAT
ATTGATAATACCTACCGAAATTTTGAAATGGAAGTACTATCTGGAGAGGAGAATATGATG
ACAAAGGTTCGAGAAAACAATTACACCTATGAATTTGATTTTTCAAAAGTCTACTGGAAT
CCTCGTCTCTCCACAGAACACAGCCGTATCACAGAACTTCTCAAACCTGGGGATGTCCTA
TTTGATGTCTTTGCTGGGGTTGGGCCCTTTGCCATTCCAGCAGCAAAGAAAAAGTGCACT
GTGTTTGCTAATGATCTCAATCCTGAATCCCATAAATGGCTACTGCACAATTGTAAATTA
AATAAAGTGGACCAAAAGGTAAAAGTCTTTAACTTGGATGGGAGAGACTTCCTGCAAGGA
CCAGTCAGAGAAGAGTTAATGCAGCAGCTAGGACCACTGTCTAAAGAAAGAAAACACTCT
GTGCACATTGTCATGAATTTGCCAGCAAAGGCTATTGAGTTTCTCAGTGCTTTCAAAGCA
CTCTTAGAGGGACAGCCATGTGGCAGTGAACTCCTTCCCATTGTGCACTGTTACAGCTTT
TCCAAAGATGCTAATCCAGCTAAGGATGTTCAGCAACGAGCTGCAACTGTGTTAGGCATC
TCCTTGGAGGCATATAGTTCAGTTCACCTAGTAAGAAATGTGGCCCCTAACAAGGAAATG
TTATGCATCACTTTTCGGATTCCTGCTGCTATACTTTACAAGAACCAGACCGTGAATCGA
GACAATCATGAAGGTCCACCTCTTAAACGCCAGAGGACAGATAAAGACTTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 497 |
| Molecular Weight
| 56954.0 |
| Theoretical pI
| 9.64 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>tRNA (guanine-N(1)-)-methyltransferase
MRSLLKQFAFSRRLLKVESCRITESASLILLPWASLIQKLNRVPVIFLLDQRKRFSTMPE
IETNHRDSELFSPPSEVRGMTELDRTAFKKTVTIPVLKVRKEVVNKLMRSLKRAALQRPG
IKRVIEDPEDGEGRLIMLDPYKMFTVDSFEKEELSILKQLNVNPQISKYNLDLTYENFKS
EEILRAVLPEGQDVTSGFSRVGHIAHLNLRDHQLPYKHLIGQVMIDKNPGITSAVNKINN
IDNTYRNFEMEVLSGEENMMTKVRENNYTYEFDFSKVYWNPRLSTEHSRITELLKPGDVL
FDVFAGVGPFAIPAAKKKCTVFANDLNPESHKWLLHNCKLNKVDQKVKVFNLDGRDFLQG
PVREELMQQLGPLSKERKHSVHIVMNLPAKAIEFLSAFKALLEGQPCGSELLPIVHCYSF
SKDANPAKDVQQRAATVLGISLEAYSSVHLVRNVAPNKEMLCITFRIPAAILYKNQTVNR
DNHEGPPLKRQRTDKDF
|
| External Links |
|---|
| GenBank ID Protein
| AAI05168.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHN8 |
| UniProtKB/Swiss-Prot Entry Name
| TRM5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105167 |
| GeneCard ID
| TRMT5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
