| Identification |
|---|
| BMDB Protein ID
| BMDBP00399 |
| Secondary Accession Numbers
| None |
| Name
| Diphthine methyl ester synthase |
| Synonyms
|
Not Available
|
| Gene Name
| DPH5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. |
| Pathways
|
- Peptidyl-diphthamide biosynthesis
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| DPH5 |
| Gene Sequence
|
>858 bp
ATGCTTTACATGATTGGTTTGGGCCTGGGAGATGCCAAGGACATCACAGTCAAGGGCCTG
GAAGTTGTCAGACGCTGCAGTCGAGTGTATCTGGAAACCTATACGTCAGTTCTGACTGTA
GGGAAAGAAGTTCTGGAAGAGTTTTATGAGAGAAAATTGATTCTTGCTGATAGAGAAGAA
GTGGAACAGGAGGCAGATAATATTTTAAAGGATGCTGATATCAGTGATGTTGCATTCCTT
GTAGTTGGTGATCCATTTGGGGCTACAACACACAGTGATCTTATTCTGAGAGCAACAAAA
CTGGGGATCCCTTATAGAGTTATTCACAATGCATCCATAATGAATGCTGTAGGCTGCTGC
GGTTTGCAGTTGTATAAGTTTGGAGAGACAGTGTCTATTGTTTTCTGGACAGACACTTGG
AGACCAGAAAGCTTCTTTGACAAAGTGAAGAAGAACAGACAAAATGGCATGCACACATTA
TGCCTACTAGACATCAAAGTAAAGGAGCAGTCTTTGGAAAATCTAATCAAGGGAAGAAAG
ATCTATGAACCTCCTCGGTATATGAGTGTCAACCAAGCAGCCCAGCAACTTCTGGAGATT
GTTCAGAATCAGCGAATACGAGGAGAAGAACCAGCAGTCACCGAGGAGACACTCTGTGTT
GGCTTAGCCAGGGTTGGCGCTGAGGACCAGAAAATTGCAGCAGGCACTTTGCAGCAGATG
TCTACTGTGGACTTGGGAGGACCATTGCATTCCTTGATTATCACTGGAGGCAGCTTGCAT
CCACTGGAGATGGAGATGCTAAGTCTGTTTACCATACCAGAAAATAGCTCAGAAGCCCAA
AGCATTGGTGGACTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 285 |
| Molecular Weight
| 31662.0 |
| Theoretical pI
| 4.86 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Diphthine synthase
MLYMIGLGLGDAKDITVKGLEVVRRCSRVYLETYTSVLTVGKEVLEEFYERKLILADREE
VEQEADNILKDADISDVAFLVVGDPFGATTHSDLILRATKLGIPYRVIHNASIMNAVGCC
GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK
IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGAEDQKIAAGTLQQM
STVDLGGPLHSLIITGGSLHPLEMEMLSLFTIPENSSEAQSIGGL
|
| External Links |
|---|
| GenBank ID Protein
| AAX09055.1 |
| UniProtKB/Swiss-Prot ID
| Q5E982 |
| UniProtKB/Swiss-Prot Entry Name
| DPH5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021038 |
| GeneCard ID
| DPH5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
