| Identification |
|---|
| BMDB Protein ID
| BMDBP00397 |
| Secondary Accession Numbers
| None |
| Name
| Protein-L-isoaspartate(D-aspartate) O-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| PCMT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| Not Available |
| SNPs
| PCMT1 |
| Gene Sequence
|
>684 bp
ATGGCCTGGAAATCCGGCGGCGCCAGCCACTCGGAGCTAATCCACAACCTCCGCAAAAAT
GGAATCATCAAGACAGATAAAGTGTTTGAAGTAATGTTGGCCACAGACCGCTCCCACTAT
GCAAAATGTAACCCTTATATGGATTCTCCACAATCAATAGGGTTCCAAGCAACAATCAGT
GCTCCACACATGCATGCATATGCACTAGAACTTCTATTTGATCAGTTGAATGAAGGAGCT
AAAGCTCTTGATGTAGGATCTGGAAGTGGAATCCTTACTGCATGTTTTGCACGTATGGTT
GGACCTAGTGGGAAAGTCATAGGAATTGACCACATTAAAGAGCTAGTAGATGACTCAATA
AATAATGTCAGAAAGGATGATCCAATGCTTTTGTCTACAGGGAGGGTGCAACTGGTTGTG
GGGGATGGACGAATGGGATATGCCGCAGAAGCCCCTTATGATGCTATTCACGTAGGAGCT
GCAGCCCCAGTTGTGCCCCAGGCACTAATAGACCAGTTAAAGCCTGGTGGAAGATTGATA
TTGCCAGTTGGTCCTGCAGGTGGAAACCAGATGTTGGAGCAGTATGACAAGCTGCAAGAT
GGCAGTGTCAAAATGAAACCTCTGATGGGAGTGATATACGTGCCTTTAACAGATAAAGAA
AAGCAGTGGTCCAGGTGGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 227 |
| Molecular Weight
| 24565.0 |
| Theoretical pI
| 7.69 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein-L-isoaspartate(D-aspartate) O-methyltransferase
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATIS
APHMHAYALELLFDQLNEGAKALDVGSGSGILTACFARMVGPSGKVIGIDHIKELVDDSI
NNVRKDDPMLLSSGRVQLVVGDGRMGYAAEAPYDAIHVGAAAPVVPQALIDQLKPGGRLI
LPVGPAGGNQMLEQYDKLQDGSVKMKPLMGVIYVPLTDKEKQWSRWK
|
| External Links |
|---|
| GenBank ID Protein
| AAI09664.1 |
| UniProtKB/Swiss-Prot ID
| P15246 |
| UniProtKB/Swiss-Prot Entry Name
| PIMT_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC109663 |
| GeneCard ID
| PCMT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
