| Identification |
|---|
| BMDB Protein ID
| BMDBP00369 |
| Secondary Accession Numbers
| |
| Name
| 3-ketoacyl-CoA thiolase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACAA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs (By similarity). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (By similarity). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity). |
| Pathways
|
- Fatty Acid Metabolism
- Lipid metabolism
|
| Reactions
|
| Coenzyme A + Acetoacetyl-CoA →2 Acetyl-CoA |
details
|
| 2-Methylacetoacetyl-CoA + Coenzyme A → Propionyl-CoA + Acetyl-CoA |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 24 |
| Locus
| Not Available |
| SNPs
| ACAA2 |
| Gene Sequence
|
>1194 bp
ATGGCCCTGCTCCGAGGTGTGTTCATCGTCGCTGCTAAGCGGACCCCCTTTGGAGCTTAT
GGGGGTCTTCTGAAAGACTTCACACCTACTGACATGGCTGAGTTTGCTGCCAGGGCTGCC
TTGTCTGCTGGCAGAGTCTCACCGGAAACTGTCGACAGTGTCGTCGTAGGCAATGTCATG
CAGAGTTCTTCAGATGCTATATACTTGGCAAGACATGTTGGTTTGCGTGTGGGAATCCCA
AAAGAGACCCCAGCTATCACTATTAACAGGCTCTGTGGCTCTGGTTTCCAGTCCATTGTG
AGTGGATGTCAGGAAATTTGTTCTAGAGACTCTGAAGTTGTCCTGTGTGGAGGAACTGAA
AGCATGAGCCAGGCTCCCTACTGTGTCAGAAATATTCGTTTTGGAACTAAGCTTGGATCA
GAGCTCAAGCTGGAAGACACTCTGTGGACAGGATTAACAGATACGCATGTCCAAATGCCG
ATGGCAATTACTGCAGAGAATCTTGCTGTAAAACATCAAATAAGCAGAGAAGATTGTGAC
AGATACGCCCTGCAATCACAGCAGAGGTGGAAAACTGCTAATGATGCTGGCTACTTTGAT
AATGAGATGGCACCAGTTGAGGTGAAGACAAGGAAAGGAAAACAGACAATGCAAGTAGAT
GAACATCCTCGGCCCCAAACAACCATGGAGCAGTTAAATAAACTTCCTCCAGTGTTCAAG
AAAGAAGGAACCGTTACTGCAGGGAATGCGTCGGGGGTTTCCGATGGTGCTGGAGCTGTT
ATCATAGCTAGTGAAGATGCTGTTAAAAAACATAACTTCACACCACTGGCAAGAATTGTG
GGCTATTTTGTGTCTGGATGTGATCCCACTATCATGGGTATTGGTCCCGTCCCTGCTATC
AGTGGAGCACTGAAGAAAACAGGGCTGAGTCTTAAGGATATGGATTTGGTAGAAGTGAAT
GAAGCTTTTGCTCCTCAGTACTTGGCAGTTGAAAAGAGTTTGAATCTTGACCCAAGTAAG
ACCAATGTGAATGGAGGGGCCATTGCTTTGGGTCACCCATTAGCAGGATCTGGGTCAAGA
ATTACTGCACACCTGGTTCATGAATTAAGGCGTCGGGGTGGAAAATATGCTGTAGGATCA
GCCTGCATTGGAGGTGGCCAAGGAATTGCGGTCATCATCGAGAACACAGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 397 |
| Molecular Weight
| 42131.0 |
| Theoretical pI
| 8.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>3-ketoacyl-CoA thiolase, mitochondrial
MALLRGVFIVAAKRTPFGAYGGLLKDFTPTDMAEFAARAALSAGRVSPETVDSVVVGNVM
QSSSDAIYLARHVGLRVGIPKETPAITINRLCGSGFQSIVSGCQEICSRDSEVVLCGGTE
SMSQAPYCVRNIRFGTKLGSELKLEDTLWTGLTDTHVQMPMAITAENLAVKHQISREDCD
RYALQSQQRWKTANDAGYFDNEMAPVEVKTRKGKQTMQVDEHPRPQTTMEQLNKLPPVFK
KEGTVTAGNASGVSDGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPTIMGIGPVPAI
SGALKKTGLSLKDMDLVEVNEAFAPQYLAVEKSLNLDPSKTNVNGGAIALGHPLAGSGSR
ITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIENTA
|
| External Links |
|---|
| GenBank ID Protein
| ABU62844.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0R7 |
| UniProtKB/Swiss-Prot Entry Name
| THIM_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| EF583004 |
| GeneCard ID
| ACAA2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
