| Identification |
|---|
| BMDB Protein ID
| BMDBP00261 |
| Secondary Accession Numbers
| None |
| Name
| Squalene synthase |
| Synonyms
|
Not Available
|
| Gene Name
| FDFT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway. |
| Pathways
|
- Lanosterol biosynthesis
- Lanosterol from farnesyl diphosphate: step 1/3
- Steroid Biosynthesis
- Terpene metabolism
|
| Reactions
|
| 2 Farnesyl pyrophosphate + NADPH → Squalene + NADP +2 Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| FDFT1 |
| Gene Sequence
|
>1254 bp
ATGGAGTTCGTGAAGTGCTTGGGGCACCCTGAGGAGTTCTACAACCTTCTGCGCTTCCAG
ATGGGGGGCCGACGGAAGGTGATACCCAAAATGGACCAGGACTCGCTCAGCAGCAGCTTG
AAAACATGCTACAAGTACCTGAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCG
CTGGATGGGGAAATGCGCCATGCAGTATGCATATTTTATCTGGTTCTCCGAGCTTTGGAC
ACACTGGAAGATGACATGACTATCAGTATAGAAAGAAAAGTGCCACTGCTACACAACTTC
CACTCATACCTTTATGAGCCTGACTGGCGGTTCACGGAGAGCAAGGAAAAGGACCGACAA
GTCCTGGAGGACTTCCCAACGATCTCCCTGGAGTTTCGAAATCTGGCTGAGAAATATCAG
ACAGTGATTGTTGACGTTTGCCAGAAGATGGGCTTTGGGATGGCGGAGTTTCTGGATAAG
CGCGTGACGTCTGAACGGGAGTGGGACAAGTACTGTCACTATGTTGCTGGTCTAGTGGGA
ATTGGCCTCTCCCGTCTCTTCCCGGCCTCAGAGTTAGAAGACCCCTTAATTGGCGAAGAC
ACAGAGCGAGCCAACTCTATGGGCCTTTTTCTGCAGAAAACAAACATCATCCGTGATTAT
CTGGAAGACCAGCGAGAAGGGAGAGAGTTTTGGCCTCAAGAGACTTGGAGCAAGTATGTG
AAGAAGCTGGGTGACTTTGCTAAGCCAGAGAACATTGACTTGGCTGTGCAGTGTCTGAAT
GAACTCATCACCAACACACTGCACCACATCCCCGACGTCATCACCTACCTGTCACGACTT
AGAAACCAGAGTATTTTTAACTTCTGTGCTATTCCACAGGTCATGGCCATTGCTACTTTG
GCTGCCTGTTACAATAATCAGCAGGTGTTCAAGGGGGTGGTGAAGATTCGAAAAGGGCAA
GCGGTCACCCTGATGATGGATGCCACCAACATGCCAGCTGTAAAAGCCATAATACACCAG
TACATGGAAGAGATTTATCACAGAATTCCCAACTCTGACCCCTGTTCCACTAAAACACAG
CAGATCATCTCCACCATCAGGACACAGAATCTCCCCAACTGTCAGCTGGTCTCGCGGAGC
CACTACTCGCCCATCTACCTGTCGTTCGTCATGCTCCTGGCGGCCCTGAGCTGGCAGTAC
CTGAGCACCCTGTCCCAGGTCACAGAGGACTATGTTCAGACCGGGGAGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 417 |
| Molecular Weight
| 48304.0 |
| Theoretical pI
| 6.44 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Squalene synthetase
MEFVKCLGHPEEFYNLLRFQMGGRRKVIPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRHAVCIFYLVLRALDTLEDDMTISIERKVPLLHNFHSYLYEPDWRFTESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIVDVCQKMGFGMAEFLDKRVTSEREWDKYCHYVAGLVG
IGLSRLFPASELEDPLIGEDTERANSMGLFLQKTNIIRDYLEDQREGREFWPQETWSKYV
KKLGDFAKPENIDLAVQCLNELITNTLHHIPDVITYLSRLRNQSIFNFCAIPQVMAIATL
AACYNNQQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIHQYMEEIYHRIPNSDPCSTKTQ
QIISTIRTQNLPNCQLVSRSHYSPIYLSFVMLLAALSWQYLSTLSQVTEDYVQTGEH
|
| External Links |
|---|
| GenBank ID Protein
| AAI09960.1 |
| UniProtKB/Swiss-Prot ID
| Q32KR6 |
| UniProtKB/Swiss-Prot Entry Name
| FDFT_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC109959 |
| GeneCard ID
| FDFT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
