| Identification |
|---|
| BMDB Protein ID
| BMDBP00260 |
| Secondary Accession Numbers
| None |
| Name
| Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ALDH6A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. |
| Pathways
|
- beta-Alanine Metabolism
- Propanoate Metabolism
- Valine, Leucine, and Isoleucine Degradation
|
| Reactions
|
| Malonic semialdehyde + Coenzyme A + NAD → Acetyl-CoA + Carbon dioxide + NADH |
details
|
| (S)-Methylmalonic acid semialdehyde + Water + NAD + Coenzyme A → Propionyl-CoA + NADH + Hydrogen carbonate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| ALDH6A1 |
| Gene Sequence
|
>1614 bp
ATGGCGGCTGTGGCGGTGGCGGCGGCGGCGGCTGCATTGCGGGCCCGGATCCTGCAGGTC
TCTTCCAAGGTGAATTCCAGTTGGCAGCCAGCATCCTCCTTCTCTTCGTCTTCAGTGCCA
ACTGTAAAACTCTTCATTGATGGGAAATTTATTGAATCCAAAAGTGACAAATGGATCGAC
ATCCACAATCCCGCCACCAATGAGGTCATTGGTCGGGTCCCTGAGTCCACCAAGGCCGAA
ATGGATGCAGCAGTTTCTTCCTGCAAACGTACTTTTCCCGCGTGGGCAGACACTTCAATA
TTAAGCCGTCAGCAGGTCCTGCTCCGCTACCAACAACTCATTAAAGAAAATTTGAAAGAA
ATTGCCAGGTTGATCATGCTGGAACAAGGGAAGACCCTGGCGGATGCTGAAGGAGATGTG
TTTCGAGGCCTCCAGGTGGTTGAGCATGCCTGCAGTGTGACATCCCTCATGCTGGGGGAC
ACCATGCCATCCATCACCAAAGACATGGACCTTTATTCCTACCGTCTGCCTCTGGGGGTA
TGCGCAGGCATTGCTCCGTTCAATTTTCCTGCCATGATCCCCCTTTGGATGTTTCCCATG
GCCATGGTGTGTGGAAATACCTTCCTGATGAAACCATCAGAGCGAGTCCCTGGAGCAACT
ATGCTTCTCGCCAAGCTGTTTCAGGACTCTGGTGCCCCTGATGGAACACTGAATATCATC
CATGGACAACATGAAGCTGTAAATTTTATTTGCGATCATCCGGATATCAAAGCAATCAGC
TTTGTGGGATCCAACCAGGCAGGAGAGTACATCTTCGAGCGAGGGTCAAGACATGGCAAG
AGAGTTCAAGCCAATATGGGAGCCAAGAACCATGGAGTAGTCATGCCAGATGCGAATAAG
GAAAACACCCTGAACCAGTTGGTTGGGGCAGCATTTGGAGCTGCTGGTCAGCGCTGCATG
GCTCTTTCAACAGCAATCCTTGTGGGAGAAGCTAAGAAGTGGCTGCCAGAGCTGGTAGAA
CGTGCCAAAAAACTAAGAGTGAATGCAGGAGACCAGCCTGGAGCTGATCTTGGCCCTCTG
ATCACCCCCCAGGCAAAAGAGCGTGTCTGTAATCTGATTGATAGTGGAACAAAGGAAGGA
GCTTCCATCCTTCTTGACGGGCGAAGTATTAAAGTCAAAGGTTATGAAAATGGGAACTTT
GTTGGGCCAACCATCATTTCAAATGTCAAGCCAAACATGACCTGTTACAAGGAGGAGATT
TTTGGCCCAGTTCTTGTAGTTCTGGAAACAGACACTTTGGATGAAGCCATCAAGATTGTA
AATGACAACCCATATGGAAATGGAACAGCCATCTTCACCACCAATGGAGCCACTGCTCGG
AAATATTCCCACCTGGTGGATGTTGGACAGGTTGGGGTGAATGTGCCCATTCCAGTGCCT
TTGCCAATGTTCTCATTCACGGGCTCTCGCGCTTCCTTCAGGGGAGACACCAATTTCTAT
GGCAAACAGGGCATCCAATTCTATACTCAGCTAAAGACTATCACTTCTCAATGGAAAGAA
GAAGATGCTTCTCTTTCCTCACCTGCTGTAGTCATGCCTACCATGGGCCGTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 537 |
| Molecular Weight
| 58063.0 |
| Theoretical pI
| 8.2 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
MAAVAVAAAAAALRARILQVSSKVNSSWQPASSFSSSSVPTVKLFIDGKFIESKSDKWID
IHNPATNEVIGRVPESTKAEMDAAVSSCKRTFPAWADTSILSRQQVLLRYQQLIKENLKE
IARLIMLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGDTMPSITKDMDLYSYRLPLGV
CAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLFQDSGAPDGTLNII
HGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANK
ENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKWLPELVERAKKLRVNAGDQPGADLGPL
ITPQAKERVCNLIDSGTKEGASILLDGRSIKVKGYENGNFVGPTIISNVKPNMTCYKEEI
FGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVP
LPMFSFTGSRASFRGDTNFYGKQGIQFYTQLKTITSQWKEEDASLSSPAVVMPTMGR
|
| External Links |
|---|
| GenBank ID Protein
| AAA30650.1 |
| UniProtKB/Swiss-Prot ID
| Q07536 |
| UniProtKB/Swiss-Prot Entry Name
| MMSA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L08643 |
| GeneCard ID
| ALDH6A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
