| Identification |
|---|
| BMDB Protein ID
| BMDBP00253 |
| Secondary Accession Numbers
| None |
| Name
| Propionyl-CoA carboxylase beta chain, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| PCCB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). |
| Pathways
|
- Metabolic intermediate metabolism
- Propanoate Metabolism
- Propanoyl-CoA degradation
- Succinyl-CoA from propanoyl-CoA: step 1/3
- Threonine and 2-Oxobutanoate Degradation
- Valine, Leucine, and Isoleucine Degradation
|
| Reactions
|
| 3-Methylcrotonyl-CoA + Adenosine triphosphate + Hydrogen carbonate → 3-Methylglutaconyl-CoA + ADP |
details
|
| Propionyl-CoA + Adenosine triphosphate + Hydrogen carbonate → S-Methylmalonyl-CoA + ADP + Hydrogen phosphate |
details
|
| Propionyl-CoA + Hydrogen carbonate + Adenosine triphosphate → S-Methylmalonyl-CoA + ADP + Hydrogen |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q31-q36 |
| SNPs
| PCCB |
| Gene Sequence
|
>1620 bp
ATGGCTGCAGCAATGCGCGTGGCTGTGGCCGGAGCCAGGCTCAGTGTTGTACTGAGAAGT
CTCCGGGGCGCGGGGCGCAGCTTGTGCACCCAGCCTGTATCGGTTAACGAACGCATCGAG
AACAAGCGGCAAGCTGCACTGCTGGGAGGAGGGCAGCGCCGCATTGACGCGCAGCATAAG
CGAGGAAAGCTGACAGCCAGAGAGCGGATCAGTCTCTTGCTGGACCCTGGCAGTTTTGTT
GAGAGCGACATGTTTGTGGAACACAGATGTGCAGATTTTGGAATGGCTGCTGATAAGAAT
AAGTTCCCTGGAGACAGTGTGGTCACTGGACGAGGACGAATCAATGGAAGACTGGTTTAT
GTCTTCAGTCAGGATTTTACAGTTTTTGGAGGTAGCCTGTCTGGAGCACATGCCCAAAAG
ATCTGCAAAATCATGGACCAAGCCCTCACAGTGGGGGCTCCAGTGATTGGACTGAATGAC
TCTGGAGGTGCACGGATTCAAGAGGGAGTGGAATCTTTGGCTGGCTATGCAGACATCTTT
CTGAGGAATGTCACGGCATCCGGAGTCATCCCTCAGATTTCTCTGATCATGGGCCCATGT
GCTGGTGGGGCTGTCTACTCCCCAGCCTTAACAGACTTCACGTTCATGGTGAAGGACACC
TCCTACTTATTCATCACTGGCCCTGACGTTGTGAAGTCTGTCACCAATGAGGACGTTACT
CAGGAGGAACTCGGGGGTGCCAGGACCCACACCACCATGTCAGGTGTGGCCCACAGGGCT
TTTGAGAATGACGTTGATGCCTTGTGTAATCTCCGGGAATTCTTCAACTACCTGCCTCTC
AGCAATCAGGACCCAGCTCCTGTCCTTGAGTGCCATGACCCCAGTGACCGTCTGGTTCCT
GAGCTTGACACAATTGTCCCTTTGGAATCTACCAAAGCCTACAACATGGTGGACATCATA
CATGCTGTTGTGGATGAGCGAGAATTTTTTGAGATCATGCCCAATTATGCCAAGAACATC
ATTGTTGGTTTTGCAAGAATGAACGGGAGGACTGTTGGAATTGTTGGCAACCAACCTAAG
GTGGCTTCAGGCTGCTTGGACATTAATTCTTCTGTGAAAGGGGCTCGTTTCGTCCGATTC
TGTGACTCGTTCAACATTCCCCTCATCACTTTTGTGGATGTCCCCGGCTTCCTGCCTGGC
ACCGCGCAGGAGTATGGGGGCATCATCCGCCACGGCGCCAAGCTGCTGTACGCGTTTGCA
GAGGCCACTGTGCCCAAAGTGACGGTCATCACCAGGAAGGCCTACGGTGGTGCCTATGAT
GTCATGAGCTCCAAGCACCTCTGTGGTGACACCAACTACGCCTGGCCCACGGCAGAGATT
GCAGTCATGGGAGCAAAGGGTGCTGTGGAGATCATCTTCAAAGGGCACGAGAACGTGGAG
GCTGCTCAGGCAGAGTACATCGAGAAGTTTGCCAACCCTTTTCCTGCAGCCGTGAGAGGG
TTTGTGGACGACATCATCCAGCCTTCTTCCACACGTGCCCGAATCTGCTGTGACCTGGAT
GTCCTGGCCAGCAAGAAGGTACAGCGCCCTTGGAGGAAACATGCGAATATTCCATTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 539 |
| Molecular Weight
| 58311.0 |
| Theoretical pI
| 7.48 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Propionyl-CoA carboxylase beta chain, mitochondrial
MAAAMRVAVAGARLSVVLRSLRGAGRSLCTQPVSVNERIENKRQAALLGGGQRRIDAQHK
RGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVY
VFSQDFTVFGGSLSGAHAQKICKIMDQALTVGAPVIGLNDSGGARIQEGVESLAGYADIF
LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVT
QEELGGARTHTTMSGVAHRAFENDVDALCNLREFFNYLPLSNQDPAPVLECHDPSDRLVP
ELDTIVPLESTKAYNMVDIIHAVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPK
VASGCLDINSSVKGARFVRFCDSFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFA
EATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVE
AAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRKHANIPL
|
| External Links |
|---|
| GenBank ID Protein
| AAI09785.1 |
| UniProtKB/Swiss-Prot ID
| Q2TBR0 |
| UniProtKB/Swiss-Prot Entry Name
| PCCB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109784 |
| GeneCard ID
| PCCB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
