| Identification |
|---|
| BMDB Protein ID
| BMDBP00205 |
| Secondary Accession Numbers
| None |
| Name
| Activin receptor type-1 |
| Synonyms
|
Not Available
|
| Gene Name
| ACVR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in activin receptor activity, type I |
| Specific Function
| On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May also bind activin. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| ACVR1 |
| Gene Sequence
|
>1530 bp
ATGGTGGATGGAGTGATGATTCTTCCTGTGCTCGTGATGATTGCTTTCCCTTTCCCTAGT
ATGGAAGATGAGAAGCCCAAGGTAAACCCCAAGCTTTACATGTGTGTGTGTGAAGGCCTC
TCCTGTGGGGATGAGGCCCACTGTGAAGGCCAGCAGTGCTTTTCCTCGCTGAGCATAAAT
GATGGCTTCCACGTCTACCAGAAAGGCTGCTTCCAGGTCTACGAGCAGGGGAAGATGACC
TGTAAGACCCCGCCGTCACCTGGCCAGGCTGTGGAGTGCTGCCAAGGGGACTGGTGTAAC
AGGAACATCACGGCCCAGCTGCCTACTAAAGGGAAATCTTTTCCTGGAACACAGAATTTC
CACTTGGAGGTTGGCCTCATCATTTTGTCTGTAGTGTTCGCAGTATGCCTTCTAGCCTGC
CTATTGGGAGTTGCTCTCCGAAAATTTAAAAGGCGCAATCAAGAACGCCTCAACCCCAGA
GATGTGGAATATGGCACCATTGAAGGACTCATCACCACCAACGTTGGAGACAGCACTTTA
GCAGATTTATTGGATCATTCATGTACATCGGGAAGCGGCTCTGGCCTTCCTTTTCTGGTA
CAGAGAACAGTGGCCCGTCAGATCACACTGCTGGAGTGTGTTGGGAAGGGCAGGTATGGC
GAGGTGTGGAGGGGCAGCTGGCAAGGGGAGAACGTCGCTGTGAAGATCTTTTCCTCCCGG
GATGAGAAGTCGTGGTTTAGGGAAACAGAATTGTACAACACTGTGATGCTGAGGCATGAA
AATATCTTAGGTTTCATTGCTTCAGACATGACATCAAGACACTCCAGTACACAGTTGTGG
TTGATCACACATTATCATGAAATGGGATCGCTGTACGACTACCTTCAGCTTACTACTCTG
GATACAGTGAGCTGCCTGAGAATAGTGCTGTCCATAGCGAGCGGTCTCGCACATTTGCAC
ATAGAGATCTTTGGGACCCAAGGGAAACCGGCCATTGCTCACCGAGATCTAAAAAGCAAA
AACATCCTGGTTAAGAAGAATGGACAGTGTTGCATAGCAGATTTGGGCCTGGCAGTCATG
CATTCCCAGAGCACCAATCAGCTCGATGTGGGGAACAACCCCCGTGTGGGCACCAAACGC
TACATGGCCCCCGAAGTTCTTGATGAAACTATCCAGGTGGATTGTTTCGATTCTTACAAG
AGAGTCGATATTTGGGCCTTTGGACTTGTCTTGTGGGAGGTGGCCAGGCGGATGGTGAGC
AATGGTATTGTGGAGGATTACAAGCCACCATTCTATGATGTGGTTCCCAATGACCCAAGT
TTTGAAGATATGAGGAAGGTAGTCTGTGTGGATCAACAGAGGCCTAACATACCCAACAGA
TGGTTCTCAGACCCGACATTAACCTCCCTGGCCAAGCTGATGAAAGAATGCTGGTATCAA
AATCCATCTGCCAGACTCACAGCCCTGCGTATCAAAAAGACTTTGACCAAAATTGATAAT
TCCCTAGACAAATTGAAAACTGACTGTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 509 |
| Molecular Weight
| 57190.0 |
| Theoretical pI
| 7.36 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Activin receptor type-1
MVDGVMILPVLVMIAFPFPSMEDEKPKVNPKLYMCVCEGLSCGDEAHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
|
| External Links |
|---|
| GenBank ID Protein
| AAB02696.1 |
| UniProtKB/Swiss-Prot ID
| Q28041 |
| UniProtKB/Swiss-Prot Entry Name
| ACVR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U58095 |
| GeneCard ID
| ACVR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
