| Identification |
|---|
| BMDB Protein ID
| BMDBP00165 |
| Secondary Accession Numbers
| None |
| Name
| Glucose-6-phosphatase |
| Synonyms
|
Not Available
|
| Gene Name
| G6PC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glucose-6-phosphatase activity |
| Specific Function
| Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). |
| Pathways
|
- Carbohydrate biosynthesis
- Galactose Metabolism
- Gluconeogenesis
- Glycolysis
- Lactose Synthesis
|
| Reactions
|
| Glucose 1-phosphate + Water → D-Glucose + Hydrogen phosphate |
details
|
| Glucose 6-phosphate + Water → D-Glucose + Hydrogen phosphate |
details
|
| Alpha-D-Glucose + Hydrogen phosphate → Glucose 6-phosphate + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| G6PC |
| Gene Sequence
|
>1074 bp
ATGGAGAAGGGAATGAACGTTCTACATGACTTTGGGATCCAGTCAACACACTACCTCCAG
GTGAATTACCAGAACTCCCAGGATTGGTTCATCTTGGTGTCTGTGATTGCAGATCTCAGG
AATGCCTTTTATGTCCTCTTCCCCATTTGGTTCCATCTTCGAGAAGCTGTGGGCATCAAA
CTCCTCTGGGTAGCTGTGATTGGAGATTGGCTCAACCTCGTCTTTAAGTGGATTCTCTTT
GGACAGCGCCCATACTGGTGGGTTTTGGATACCGACTACTACAGCAACACCTCGGCACCG
CTGATAAAGCAGTTCCCGGTCACCTGTGAGACCGGCCCAGGGAGTCCCTCTGGCCACGCC
ATGGGTACAGCAGGTGTATACTATGTGATGGTCACATCCACCCTCTCTATCTTTCGTGGA
AAGAAAAAGCCAACCTACAGATTTCGGTGCTTGAATGTCATGTTGTGGTTGGGATTCTGG
GTCGTGCAACTGAATGTCTGCCTGTCACGAATCTACCTTGCTGCTCATTTTCCCCATCAA
GTTGTTGCTGGAGTCTTGTCAGGCATTGCGGTTGCTGAGACTTTCCGCCACATCCAGAGC
ATCTACAATGCCAGTCTCAAGAAGTACTTTCTCATCACCTGCTTCCTGTTCAGTTTCGCC
ATTGGATTTTACCTGCTGTTAAAGTGGCTGGGGGTCGACCTGCTGTGGACTCTAGAGAAA
GCCAAGCGAAGGTGTGAGCGGCCGGAGTGGGTCCACATTGATACAACGCCCTTTGCCAGC
CTCCTCAAGAATCTGGGGACCCTCTTTGGCTTGGGTCTGGCTCTCAACTCTAGCATGTAC
CGGGAGAGCTGCAAGGGCAAGCTCAGCAAGTGGTTCCCGTTTCGCCTCAGCTGCATCGTG
GCCTCCCTCGTCCTCCTGCACCTCTTTGACTCTTTGAAACCCCCCTCCCAAATCGAGCTG
ATCTTCTATGTCCTGTCCTTCTGCAAGAGTGCAGCGGTGCCCCTGGCATCTGTCAGCCTC
ATCCCCTACTGCCTCGCCTGGGTGCTGGGCCAGCCCAACAAGAAGACTGTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 357 |
| Molecular Weight
| 40827.0 |
| Theoretical pI
| 9.66 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 29-49
- 61-81
- 118-138
- 148-168
- 171-191
- 210-230
- 255-275
- 292-312
- 321-341
|
| Protein Sequence
|
>Glucose-6-phosphatase
MEKGMNVLHDFGIQSTHYLQVNYQNSQDWFILVSVIADLRNAFYVLFPIWFHLREAVGIK
LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSAPLIKQFPVTCETGPGSPSGHA
MGTAGVYYVMVTSTLSIFRGKKKPTYRFRCLNVMLWLGFWVVQLNVCLSRIYLAAHFPHQ
VVAGVLSGIAVAETFRHIQSIYNASLKKYFLITCFLFSFAIGFYLLLKWLGVDLLWTLEK
AKRRCERPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWFPFRLSCIV
ASLVLLHLFDSLKPPSQIELIFYVLSFCKSAAVPLASVSLIPYCLAWVLGQPNKKTV
|
| External Links |
|---|
| GenBank ID Protein
| AAI14012.1 |
| UniProtKB/Swiss-Prot ID
| Q29RU6 |
| UniProtKB/Swiss-Prot Entry Name
| G6PC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114011 |
| GeneCard ID
| G6PC |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
