| Identification |
|---|
| BMDB Protein ID
| BMDBP00130 |
| Secondary Accession Numbers
| None |
| Name
| Sphingomyelin phosphodiesterase |
| Synonyms
|
Not Available
|
| Gene Name
| SMPD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity, acting on glycosyl bonds |
| Specific Function
| Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| SMPD1 |
| Gene Sequence
|
>1878 bp
ATGCCCCGCCATGGAGTTTCTCCCGGCCAGGGCCTCCCCAGGTCGGGCCGGGAGCAGGCA
TCGGACAGGTCCTTAGGGGCCCCCTGTCTGAGGCTCCTGTGGTTGGGCTTGGCGCTGGCG
CTGGCACTGCCCAACTCCCCGGTCCTCTGGTCCCCTGCGGAGGCCCGCCCTCTTCCTACC
CAAGGCCATCCCGCCAAGTTCATTCGCATAGCGCCCCAGCTCCAGGAGGCCTTTGGCTGG
TGGAACCTCACCTGCCCAACCTGCAAAGGACTGTTCACCGCCATCGACTTCGGGCTGAGG
AATCAGGCCAGTGTGGCCTGGGTGGGCTCTGTGGCCATCAAGCTGTGCGTGCTGCTGAAG
ATCGCGCCGCCTGCCGTGTGCCAGTCAGCTGTCCAGCTCTTCGAGGACGACATGGTGGAG
GTGTGGACACGCTCAGTGCTGAGCCCGTCGGAGGCCTGTGGTCTGCTGCTGGGCTCTTCC
TGTGGGCACTGGGACATCTTCTCCTCTTGGAACATCTCTCTGCCAGCCGTGCCAAAGCCG
CCCCCCCAGCCGCCCAAGCCCCCAGCCCCAGGCTCCCCTGTCAGCCGCGTCCTCTTTCTC
ACTGATCTGCACTGGGATCACGACTACCTGGAAGGCACAGACCCCAACTGTGAGAACCCA
CTGTGTTGCCGCCGGGATTCTGGCCCACCGCCTGCCTCCCAGCCCGGTGCTGGGTACTGG
GGCGAGTATAGCAAGTGTGACCTGCCCCTGCGAACCCTGGAGAGCCTGTTGAGTGGGCTG
GGCCCCGCCGGCCCTTTTGATATGGTGTACTGGACAGGAGACATCCCTGCTCACAACATC
TGGCAGCAGTCTCGTCAGGACCAGCTGCGGGCGCTGACCACCATCACAGCCCTTGTGAAG
AAGTTCTTGGGGCCCGTGCCAGTGTACCCTGCTGTGGGCAACCACGAGAGCACACCCGTC
AACGGCTTCCCTCCCCCCTTCATAAAGGGCAACCAGTCTTCCCACTGGCTCTATGAGGCG
ATGGCCGAGGCGTGGGAGCCCTGGCTGCCGGCTGAAGCCCTTCGCACCCTCAGAATTGGG
GGGTTCTATGCCCTTTCCCCACGCCCTGGCCTCCGCCTCATCTCTCTCAACATGAATTTC
TGTTCCCGTGAGAACTTCTGGCTTTTGATCAACTCCACAGATCCTGCTGGACAGCTCCAG
TGGCTGGTGGGGGAGCTTCAGGCCGCTGAGGACCGGGGAGACAAAGTGCACATAATTGGC
CACATTCCCCCAGGGCACTGCCTGAAGAGCTGGAGCTGGAATTATTACAGAATTGTGGAA
AGGTATGAGAACACCTTGGCTGGTCAGTTCTTTGGTCACACCCACGTGGATGAGTTTGAG
GTCTTCTATGACGAAGAGACCCTCAGCCGGCCGCTGTCTGTAGCCTTCCTGGCGCCCAGT
GCCACCACCTACATCGGCCTTAATCCTGGGTACCGTGTCTACCAAATAGACGGTAACTAC
TCTGGGAGCTCTCACGTGGTCCTGGACCATGAGACCTACATCATGAATCTGACGGAGGCG
AACGAGCCCGGAGCCACGCCGCACTGGTACCTCCTCTATAGGGCTCGGGAAACCTATGGG
CTGCCCAATGCGCTGCCCACTGCCTGGCACGACCTGGTGTACCGCATGCGGAAGGACACA
CAGCTTTTCCAGACCTTCTGGTTTCTCTACCATAAGGGCCACCCGCCCTCGGAGCCCTGC
GGCACACCCTGCCGCCTCGCTACCCTGTGTGCCCAGCTCTCCGCCCGCTCAGACAGCCCT
GCTCTGTGTCGCCACCTGGTGCCGGATGCAAGCCTCCCTGATGTCCAGAGCCTGTGGTCA
ATGCCACTGTTGTGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 625 |
| Molecular Weight
| 69392.0 |
| Theoretical pI
| 6.58 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sphingomyelin phosphodiesterase
MPRHGVSPGQGLPRSGREQASDRSLGAPCLRLLWLGLALALALPNSPVLWSPAEARPLPT
QGHPAKFIRIAPQLQEAFGWWNLTCPTCKGLFTAIDFGLRNQASVAWVGSVAIKLCVLLK
IAPPAVCQSAVQLFEDDMVEVWTRSVLSPSEACGLLLGSSCGHWDIFSSWNISLPAVPKP
PPQPPKPPAPGSPVSRVLFLTDLHWDHDYLEGTDPNCENPLCCRRDSGPPPASQPGAGYW
GEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHNIWQQSRQDQLRALTTITALVK
KFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSHWLYEAMAEAWEPWLPAEALRTLRIG
GFYALSPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIG
HIPPGHCLKSWSWNYYRIVERYENTLAGQFFGHTHVDEFEVFYDEETLSRPLSVAFLAPS
ATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYIMNLTEANEPGATPHWYLLYRARETYG
LPNALPTAWHDLVYRMRKDTQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARSDSP
ALCRHLVPDASLPDVQSLWSMPLLC
|
| External Links |
|---|
| GenBank ID Protein
| AAI19882.1 |
| UniProtKB/Swiss-Prot ID
| Q0VD19 |
| UniProtKB/Swiss-Prot Entry Name
| ASM_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC119881 |
| GeneCard ID
| SMPD1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
