| Identification |
|---|
| BMDB Protein ID
| BMDBP00106 |
| Secondary Accession Numbers
| None |
| Name
| Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| NMNAT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). |
| Pathways
|
- Cofactor biosynthesis
- Deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1
- NAD(+) biosynthesis
- NAD(+) from nicotinamide D-ribonucleotide: step 1/1
- Nicotinate and Nicotinamide Metabolism
|
| Reactions
|
| NAD + Pyrophosphate → Nicotinamide ribotide + Adenosine triphosphate |
details
|
| Nicotinic acid mononucleotide + Adenosine triphosphate → Nicotinic acid adenine dinucleotide + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| NMNAT2 |
| Gene Sequence
|
>924 bp
ATGACCGAGACCACCAAGACGCACGTTATCTTGCTCGCCTGCGGCAGCTTCAATCCCATC
ACCAAAGGGCACATTCAGATGTTCGAAAGAGCCAGGGATTATCTGCACAAAACTGGAAGG
TTTATTGTCATTGGCGGGATCGTGTCTCCTGTCCACGACTCCTATGGAAAACAGGGTCTT
GTGTCAAGCCGGCACCGTCTCATCATGTGTCAGCTGGCCGTCCAGAATTCTGACTGGATC
AGGGTGGACCCATGGGAGTGCTACCAGGACACCTGGCAGACGACCTGCAGCGTCCTCGAA
CACCATCGGGACCTCATGAAGCGGGTGACTGGCTGCATCCTCTCCAACGTCAACACACCC
TCCATGACACCTGTGATCGGACAGCCCCGAAATGAGACCTCCCAACCCATCTACCAGAAC
AACAACGCTCCCAGCAAGCCCACTGCAGCCAAGATCCTGGGAAAGGTGGGAGAAAGCCTG
AGCCGGATCTGCTGTGTCCGCCCGCCAGTGGAGCGTTTCACCTTTGTGGATGAGAATGCC
AACCTGGGCACGGTGATGCGGTACGAGGAGATCGAGCTACGGATCTTGCTGCTGTGTGGC
AGTGACCTTCTGGAGTCCTTCTGCATCCCAGGACTGTGGAACGAGGCAGATATGGAGGTG
ATCGTTGGGGACTTTGGGATCGTGGTGGTCCCCCGGGACGCAGCCGACACAGACCGAATC
ATGAACCACTCTTCAATACTCCGCAAATACAAAAATAACATCATGGTGGTGAAGGATGAC
ATCAACCATCCCATGTCTGTGGTCAGCTCAACCAAGAGCAGGCTGGCTCTGCAGCACGGG
GATGGCCACGTCGTGGATTACCTGTCCCAGCCGGTCATCGACTACATTCTCAAGAGCCAG
CTGTACATCAACGCCTCGGGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 307 |
| Molecular Weight
| 34468.0 |
| Theoretical pI
| 7.28 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nicotinamide mononucleotide adenylyltransferase 2
MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL
VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP
SMTPVIGQPRNETSQPIYQNNNAPSKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA
NLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRI
MNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQ
LYINASG
|
| External Links |
|---|
| GenBank ID Protein
| AAI20345.1 |
| UniProtKB/Swiss-Prot ID
| Q0VC59 |
| UniProtKB/Swiss-Prot Entry Name
| NMNA2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120344 |
| GeneCard ID
| NMNAT2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
