| Identification |
|---|
| BMDB Protein ID
| BMDBP00086 |
| Secondary Accession Numbers
| None |
| Name
| Serine--tRNA ligase, cytoplasmic |
| Synonyms
|
Not Available
|
| Gene Name
| SARS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. |
| Pathways
|
- Aminoacyl-tRNA biosynthesis
- Glycine and Serine Metabolism
- L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1
- Protein Synthesis: Serine
- Selenocysteinyl-tRNA(Sec) biosynthesis
|
| Reactions
|
| L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| SARS1 |
| Gene Sequence
|
>1545 bp
ATGGTGCTGGATCTGGATTTGTTTCGGGTGGATAAAGGGGGGGACCCAGCACTCATCCGA
GAGTCGCAGGAGAAGCGCTTCAAGGACCCGGGACTGGTGGACCAGCTGGTGAAGGCAGAC
AGCGAGTGGCGACGATGCAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGC
AGCAAGACAATTGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAAATGATGAGTCCATT
CCAGAAGATGTATTAAATCTCGATGACCTCACTGCAGACACTTTAACTAACCTAAAAGTC
TCACAGATCAAAAAAGTCCGCCTCCTCGTCGACGAAGCCATCCTGAAGTGTGACGCCGAG
CGGATAAAACTGGAAGCTGAGCGGTTTGAGAGCCTTCGGGAGATCGGGAACCTCCTGCAC
CCGTCGGTGCCCATCAGCGATGACGAGGATGCCGACAACAAAGTAGAGAGGATTTGGGGT
GATTGTACAGTCAGGAAGAAGTACTCTCACGTGGACCTGGTGGTGATGGTAGATGGCTTT
GAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCCTGAAGGGGGTCCTG
GTGTTCCTGGAACAAGCACTCATCCAGTTTGCCCTTCGGACCTTGGCAAGTCGGGGCTAC
ACTCCCATTTATACCCCCTTCTTCATGAGGAAGGAGGTCATGCAGGAAGTGGCACAGCTC
AGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGAT
AACTCCTATGAGGAGAAATATCTGATTGCTACCTCTGAACAACCCATTGCTGCTCTTCAC
CGGGACGAGTGGCTTCGGCCAGAGGACTTGCCAATCAAGTATGCCGGCCTGTCCACCTGC
TTTCGCCAGGAGGTGGGCTCCCATGGGCGTGACACCCGTGGCATCTTTAGAGTCCATCAG
TTTGAGAAGATAGAGCAGTTTGTNTACTCCTCGCCACACGACAACAAGTCCTGGGAGATG
TTTGAGGAGATGATTGCCACCGCGGAGGAGTTCTACCAGTCTCTGGGGATCCCTTACCAC
ATCGTGAATATCGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAG
GCCTGGTTTCCAGGCTCGGGGGCCTTCCGTGAGTTAGTCTCCTGTTCTAACTGCACAGAC
TATCAGGCTCGCCGGCTCCGAATCCGATATGGGCAGACCAAGAAGATGATGGACAAGGTG
GAGTTTGTCCACATGCTCAATGCCACCATGTGTGCCACAACCCGCACCATCTGTGCCATC
CTGGAGAACTACCAGACAGAGAAGGGCATCCTCGTGCCTGAGAAATTGAAGGAATTCATG
CCGCCAGGTCTCCAAGAACTGATCCCCTTTGTGAAGGCTGCGCCCATTGACCAGGAGCCC
TCCAAGAAGCAGAAGAAGCAGCATGAGGGCAGCAAGAAGAAAGGGGCAGCGAGAGATGTT
GCCCTGGAGAGCCAGCTGCAGAACATGGAGGTCACCGATGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 514 |
| Molecular Weight
| 58605.0 |
| Theoretical pI
| 6.07 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Seryl-tRNA synthetase, cytoplasmic
MVLDLDLFRVDKGGDPALIRESQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
SKTIGEKMKKKEPVGNDESIPEDVLNLDDLTADTLTNLKVSQIKKVRLLVDEAILKCDAE
RIKLEAERFESLREIGNLLHPSVPISDDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGF
EGEKGAVVAGSRGYFLKGVLVFLEQALIQFALRTLASRGYTPIYTPFFMRKEVMQEVAQL
SQFDEELYKVIGKGSEKSDDNSYEEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMIATAEEFYQSLGIPYH
IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV
EFVHMLNATMCATTRTICAILENYQTEKGILVPEKLKEFMPPGLQELIPFVKAAPIDQEP
SKKQKKQHEGSKKKGAARDVALESQLQNMEVTDA
|
| External Links |
|---|
| GenBank ID Protein
| AAG03084.1 |
| UniProtKB/Swiss-Prot ID
| Q9GMB8 |
| UniProtKB/Swiss-Prot Entry Name
| SYSC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF297553 |
| GeneCard ID
| SARS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
