1.0 2018-12-04 20:29:22 UTC 2020-06-04 20:42:49 UTC BMDB0063639 BMDB63639 Tylosin Tylosin is used in treatment of cattle, swine and mycoplasmas in poultry Tylosin is a macrolide-class antibiotic used in veterinary medicine. It has a broad spectrum of activity against gram positive organisms and a limited range of gram negative organisms. It is found naturally as a fermentation product of Streptomyces fradiae. Tylan Tylosin hydrochloride Tylosin tartrate (salt) Tylosine Tartrate, tylosin Tylosin tartrate Hydrochloride, tylosin Fradizine Corvel-tylocine Dehydrorelomycin elanco-m Frazidine norco T-2 Parkenova Tylon Tylosin C46H77NO17 916.1001 915.519150043 2-[(11E,13E)-6-({5-[(4,5-dihydroxy-4,6-dimethyloxan-2-yl)oxy]-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl}oxy)-16-ethyl-4-hydroxy-15-{[(5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl)oxy]methyl}-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde 2-[(11E,13E)-6-({5-[(4,5-dihydroxy-4,6-dimethyloxan-2-yl)oxy]-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl}oxy)-16-ethyl-4-hydroxy-15-{[(5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl)oxy]methyl}-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde 1401-69-0 CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(C2O)N(C)C)C(CC=O)CC(C)C(=O)\C=C\C(\C)=C\C1COC1OC(C)C(O)C(OC)C1OC InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+ WBPYTXDJUQJLPQ-LLMNDNAOSA-N belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars. Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Aminoglycosides 1,2-aminoalcohols Acetals Alpha-hydrogen aldehydes Amino acids and derivatives Carboxylic acid esters Cyclic ketones Dialkyl ethers Disaccharides Hydrocarbon derivatives Lactones Macrolides and analogues Monocarboxylic acids and derivatives O-glycosyl compounds Organic oxides Organopnictogen compounds Oxacyclic compounds Oxanes Secondary alcohols Tertiary alcohols Trialkylamines 1,2-aminoalcohol Acetal Alcohol Aldehyde Aliphatic heteromonocyclic compound Alpha-hydrogen aldehyde Amine Amino acid or derivatives Aminoglycoside core Carbonyl group Carboxylic acid derivative Carboxylic acid ester Cyclic ketone Dialkyl ether Disaccharide Ether Glycosyl compound Hydrocarbon derivative Ketone Lactone Macrolide Monocarboxylic acid or derivatives O-glycosyl compound Organic nitrogen compound Organic oxide Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Oxacycle Oxane Secondary alcohol Tertiary alcohol Tertiary aliphatic amine Tertiary amine Aliphatic heteromonocyclic compounds Solid melting_point 131 °C water_solubility 0.005 mg/mL at 25 °C logp 1.63 logp 1.46 ALOGPS logs -3.64 ALOGPS logp 2.32 ChemAxon pka_strongest_acidic 12.45 ChemAxon pka_strongest_basic 7.2 ChemAxon iupac 2-[(11E,13E)-6-({5-[(4,5-dihydroxy-4,6-dimethyloxan-2-yl)oxy]-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl}oxy)-16-ethyl-4-hydroxy-15-{[(5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl)oxy]methyl}-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde ChemAxon average_mass 916.1001 ChemAxon mono_mass 915.519150043 ChemAxon smiles CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(C2O)N(C)C)C(CC=O)CC(C)C(=O)\C=C\C(\C)=C\C1COC1OC(C)C(O)C(OC)C1OC ChemAxon formula C46H77NO17 ChemAxon inchi InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+ ChemAxon inchikey WBPYTXDJUQJLPQ-LLMNDNAOSA-N ChemAxon polar_surface_area 238.67 ChemAxon refractivity 232.21 ChemAxon polarizability 98.82 ChemAxon rotatable_bond_count 13 ChemAxon acceptor_count 17 ChemAxon donor_count 5 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon number_of_rings 4 ChemAxon bioavailability 0 ChemAxon rule_of_five Yes ChemAxon ghose_filter Yes ChemAxon veber_rule Yes ChemAxon mddr_like_rule Yes ChemAxon Specdb::MsMs 319897 Specdb::MsMs 319898 Specdb::MsMs 319899 Specdb::MsMs 367147 Specdb::MsMs 367148 Specdb::MsMs 367149 Specdb::MsMs 2662405 Specdb::MsMs 2662406 Specdb::MsMs 2662407 Specdb::MsMs 3015603 Specdb::MsMs 3015604 Specdb::MsMs 3015605 Milk 0.0599 uM 90 samples from local markets or slaughterhouse Cristina Juan, Juan Carlos Moltó, Jordi Mañes, Guillermina Font. Determination of macrolide and lincosamide antibiotics by pressurised liquid extraction and liquid chromatography-tandem mass spectrometry in meat and milk. Volume 21, Issue 12, Supplement, December 2010, Pages 1703-1709 4865403 FDB012374 6260974 C00018311 C01457 17658 Tylosin Cristina Juan, Juan Carlos Moltó, Jordi Mañes, Guillermina Font. Determination of macrolide and lincosamide antibiotics by pressurised liquid extraction and liquid chromatography-tandem mass spectrometry in meat and milk. Volume 21, Issue 12, Supplement, December 2010, Pages 1703-1709