Showing metabocard for DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) (BMDB0007464)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (2) Show 2 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 23:37:52 UTC
Update Date2020-05-21 16:28:02 UTC
BMDB IDBMDB0007464
Secondary Accession Numbers
  • BMDB07464
Metabolite Identification
Common NameDG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0)
DescriptionDG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0), also known as dg(20:3(5z,8z,11z)/22:1(13z)/0:0) or DAG(20:3/22:1), belongs to the class of organic compounds known as 1,2-dg(20:3(5z,8z,11z)/22:1(13z)/0:0)s. These are dg(20:3(5z,8z,11z)/22:1(13z)/0:0)s containing a glycerol acylated at positions 1 and 2. DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) is possibly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) participates in a number of enzymatic reactions, within cattle. In particular, DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) can be biosynthesized from PA(20:3(5Z,8Z,11Z)/22:1(13Z)) through its interaction with the enzyme phosphatidate phosphatase. Furthermore, DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) and erucoyl-CoA can be converted into TG(20:3(5Z,8Z,11Z)/22:1(13Z)/22:1(13Z)); which is catalyzed by the enzyme dg(20:3(5z,8z,11z)/22:1(13z)/0:0) O-acyltransferase. Furthermore, DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) can be biosynthesized from PA(20:3(5Z,8Z,11Z)/22:1(13Z)) through the action of the enzyme phosphatidate phosphatase. Finally, DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) and nervonoyl-CoA can be converted into TG(20:3(5Z,8Z,11Z)/22:1(13Z)/24:1(15Z)); which is mediated by the enzyme dg(20:3(5z,8z,11z)/22:1(13z)/0:0) O-acyltransferase. In cattle, DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) is involved in a couple of metabolic pathways, which include de novo triacylglycerol biosynthesis TG(20:3(5Z,8Z,11Z)/22:1(13Z)/22:1(13Z)) pathway and de novo triacylglycerol biosynthesis TG(20:3(5Z,8Z,11Z)/22:1(13Z)/24:1(15Z)) pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
1-Meadoyl-2-erucoyl-sn-glycerolHMDB
DAG(20:3/22:1)HMDB
DAG(20:3N9/22:1N9)HMDB
DAG(20:3W9/22:1W9)HMDB
DAG(42:4)HMDB
DG(20:3/22:1)HMDB
DG(20:3N9/22:1N9)HMDB
DG(20:3W9/22:1W9)HMDB
DG(42:4)HMDB
DiacylglycerolHMDB
Diacylglycerol(20:3/22:1)HMDB
Diacylglycerol(20:3n9/22:1n9)HMDB
Diacylglycerol(20:3W9/22:1W9)HMDB
Diacylglycerol(42:4)HMDB
DiglycerideHMDB
1-(5Z,8Z,11Z-Eicosatrienoyl)-2-(13Z-docosenoyl)-sn-glycerolHMDB
DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0)Lipid Annotator
Chemical FormulaC45H80O5
Average Molecular Weight701.1137
Monoisotopic Molecular Weight700.60057567
IUPAC Name(2S)-1-hydroxy-3-[(5Z,8Z,11Z)-icosa-5,8,11-trienoyloxy]propan-2-yl (13Z)-docos-13-enoate
Traditional Namediacylglycerol
CAS Registry NumberNot Available
SMILES
[H][C@](CO)(COC(=O)CCC\C=C/C\C=C/C\C=C/CCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCCCC
InChI Identifier
InChI=1S/C45H80O5/c1-3-5-7-9-11-13-15-17-19-21-22-24-26-28-30-32-34-36-38-40-45(48)50-43(41-46)42-49-44(47)39-37-35-33-31-29-27-25-23-20-18-16-14-12-10-8-6-4-2/h17-20,25,27,31,33,43,46H,3-16,21-24,26,28-30,32,34-42H2,1-2H3/b19-17-,20-18-,27-25-,33-31-/t43-/m0/s1
InChI KeyGIVPHQLIWSGNSA-CWDOMWFGSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as 1,2-diacylglycerols. These are diacylglycerols containing a glycerol acylated at positions 1 and 2.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerolipids
Sub ClassDiradylglycerols
Direct Parent1,2-diacylglycerols
Alternative Parents
Substituents
  • 1,2-acyl-sn-glycerol
  • Fatty acid ester
  • Fatty acyl
  • Dicarboxylic acid or derivatives
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP10.6ALOGPS
logP15ChemAxon
logS-7.9ALOGPS
pKa (Strongest Acidic)14.58ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 ŲChemAxon
Rotatable Bond Count40ChemAxon
Refractivity218.18 m³·mol⁻¹ChemAxon
Polarizability91.49 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-0000000900-3824d5719eb36140e8d5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03eb-0009003100-05cc0e9252a111777efcView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03xt-0009000300-49339e87eb088304a723View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0ul0-2129012400-82fc18bd28a036c4c473View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00di-2229010000-ec04610b22fb08d0e34dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-00di-3729000000-4b77c020a97cdc754c9aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0002-1008109000-68e484f9d22a6ad54899View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0ab9-3019000000-2d7d4a19942fc43fe8a0View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-3119000000-0985d075e7e4d422c270View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-0000000900-19b8554ce51aad925d79View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03eb-0009003100-c3bbb33b815ffc20585bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03xt-0009000300-fe035bbe58d1f558deb4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-0000000900-a37a4a3b9d1bd59ad7afView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00di-0000000900-a37a4a3b9d1bd59ad7afView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0150-0009600100-5ce77139e28932dc57c2View in MoNA
Biological Properties
Cellular Locations
  • Cell membrane
  • Membrane
Biospecimen Locations
  • All Tissues
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
Abnormal Concentrations
Not Available
HMDB IDHMDB0007464
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB024657
KNApSAcK IDNot Available
Chemspider ID24766167
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound53478259
PDB IDNot Available
ChEBI IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Ethanolaminephosphotransferase 1
General function:
Involved in ethanolaminephosphotransferase activity
Specific function:
Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the foramtion of phosphatidylethanolamine via 'Kennedy' pathway (By similarity).
Gene Name:
SELENOI
Uniprot ID:
Q17QM4
Molecular weight:
45214.0
Reactions
CDP-Ethanolamine + DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) → Cytidine monophosphate + PE(20:3(5Z,8Z,11Z)/22:1(13Z))details
Enzyme Details
2. Diacylglycerol O-acyltransferase 1
General function:
Not Available
Specific function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol.
Gene Name:
DGAT1
Uniprot ID:
Q8MK44
Molecular weight:
55602.0
Reactions
DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) + Erucoyl-CoA → TG(20:3(5Z,8Z,11Z)/22:1(13Z)/22:1(13Z)) + Coenzyme Adetails
DG(20:3(5Z,8Z,11Z)/22:1(13Z)/0:0) + Clupanodonyl CoA → TG(20:3(5Z,8Z,11Z)/22:1(13Z)/22:5(7Z,10Z,13Z,16Z,19Z)) + Coenzyme Adetails