Showing metabocard for Nicotinate D-ribonucleoside (BMDB0006809)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (2) Show 2 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 23:26:17 UTC
Update Date2020-05-21 16:28:55 UTC
BMDB IDBMDB0006809
Secondary Accession Numbers
  • BMDB06809
Metabolite Identification
Common NameNicotinate D-ribonucleoside
DescriptionNicotinate D-ribonucleoside, also known as nicotinate d-ribonucleoside or beta-Nicotinate d-ribonucleoside, belongs to the class of organic compounds known as glycosylamines. Glycosylamines are compounds consisting of an amine with a beta-N-glycosidic bond to a carbohydrate, thus forming a cyclic hemiaminal ether bond (alpha-amino ether). Nicotinate D-ribonucleoside is possibly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Nicotinate D-ribonucleoside exists in all living species, ranging from bacteria to humans. Nicotinate D-ribonucleoside participates in a number of enzymatic reactions, within cattle. In particular, Nicotinate D-ribonucleoside can be converted into nicotinic acid mononucleotide through the action of the enzyme nicotinamide riboside kinase 1. In addition, Nicotinate D-ribonucleoside can be biosynthesized from nicotinic acid mononucleotide; which is catalyzed by the enzyme cytosolic purine 5'-nucleotidase. In cattle, nicotinate D-ribonucleoside is involved in the metabolic pathway called the nicotinate and nicotinamide metabolism pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
Nicotinic acid ribosideChEBI
beta-D-RibosylnicotinateKegg
Nicotinate ribosideGenerator
b-D-RibosylnicotinateGenerator
b-D-Ribosylnicotinic acidGenerator
beta-D-Ribosylnicotinic acidGenerator
Β-D-ribosylnicotinateGenerator
Β-D-ribosylnicotinic acidGenerator
Nicotinic acid D-ribonucleosideGenerator
D-RibosylnicotinateHMDB
Nicotinic acid riboseHMDB
RibosylnicotinateHMDB
Nicotinate ribonucleosideHMDB
Nicotinate riboseHMDB
Nicotinic acid ribonucleosideHMDB
3-Carboxy-1-beta-D-ribofuranosylpyridiniumHMDB
3-Carboxy-1-β-D-ribofuranosylpyridiniumHMDB
Nicotinic ribosideHMDB
Chemical FormulaC11H14NO6
Average Molecular Weight256.232
Monoisotopic Molecular Weight256.082112185
IUPAC Name3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium
Traditional Name3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium
CAS Registry NumberNot Available
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)[N+]1=CC(=CC=C1)C(O)=O
InChI Identifier
InChI=1S/C11H13NO6/c13-5-7-8(14)9(15)10(18-7)12-3-1-2-6(4-12)11(16)17/h1-4,7-10,13-15H,5H2/p+1/t7-,8-,9-,10-/m1/s1
InChI KeyPUEDDPCUCPRQNY-ZYUZMQFOSA-O
Chemical Taxonomy
Description belongs to the class of organic compounds known as glycosylamines. Glycosylamines are compounds consisting of an amine with a beta-N-glycosidic bond to a carbohydrate, thus forming a cyclic hemiaminal ether bond (alpha-amino ether).
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentGlycosylamines
Alternative Parents
Substituents
  • N-glycosyl compound
  • Pentose monosaccharide
  • Pyridine carboxylic acid
  • Pyridine carboxylic acid or derivatives
  • Monosaccharide
  • Pyridine
  • Pyridinium
  • Vinylogous amide
  • Heteroaromatic compound
  • Tetrahydrofuran
  • Secondary alcohol
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Oxacycle
  • Azacycle
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organonitrogen compound
  • Alcohol
  • Primary alcohol
  • Organic nitrogen compound
  • Organic cation
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-1.9ALOGPS
logP-5.3ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)2.76ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area111.1 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity59.01 m³·mol⁻¹ChemAxon
Polarizability24.21 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
HMDB IDHMDB0006809
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB024094
KNApSAcK IDNot Available
Chemspider ID141636
KEGG Compound IDC05841
BioCyc IDCPD-8259
BiGG ID46613
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound161234
PDB IDNot Available
ChEBI ID27748
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Cytosolic purine 5'-nucleotidase
General function:
Involved in 5'-nucleotidase activity
Specific function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
Gene Name:
NT5C2
Uniprot ID:
O46411
Molecular weight:
64841.0
Reactions
Nicotinic acid mononucleotide + Water → Nicotinate D-ribonucleoside + Hydrogen phosphatedetails
Enzyme Details
2. Nicotinamide riboside kinase 1
General function:
Not Available
Specific function:
Not Available
Gene Name:
NMRK1
Uniprot ID:
F1N5H1
Molecular weight:
22612.0
Reactions
Nicotinate D-ribonucleoside + Adenosine triphosphate → Nicotinic acid mononucleotide + ADPdetails