Showing metabocard for Selenocystathionine (BMDB0006343)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (2) Show 2 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 23:21:40 UTC
Update Date2020-05-21 16:28:22 UTC
BMDB IDBMDB0006343
Secondary Accession Numbers
  • BMDB06343
Metabolite Identification
Common NameSelenocystathionine
DescriptionSelenocystathionine, also known as selenocystathionine, belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Selenocystathionine exists as a solid, possibly soluble (in water), and a very strong basic compound (based on its pKa) molecule. Selenocystathionine exists in all living species, ranging from bacteria to humans. Selenocystathionine participates in a number of enzymatic reactions, within cattle. In particular, Selenocystathionine can be converted into selenocysteine and 2-ketobutyric acid through the action of the enzyme cystathionine gamma-lyase. In addition, Selenocystathionine can be biosynthesized from L-serine and selenohomocysteine through the action of the enzyme cystathionine beta-synthase. In cattle, selenocystathionine is involved in the metabolic pathway called the selenoamino acid metabolism pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
2-Amino-4-[(2-amino-2-carboxyethyl)selanyl]butyric acidChEBI
SelenocystathioninesChEBI
2-Amino-4-[(2-amino-2-carboxyethyl)selanyl]butyrateGenerator
2-Amino-4-((2-amino-2-carboxyethyl)seleno)-butanoateHMDB
2-Amino-4-((2-amino-2-carboxyethyl)seleno)-butanoic acidHMDB
2-Amino-4-((2-amino-2-carboxyethyl)seleno)butanoateHMDB
2-Amino-4-((2-amino-2-carboxyethyl)seleno)butanoic acidHMDB
SeCystaHMDB
Chemical FormulaC7H14N2O4Se
Average Molecular Weight269.16
Monoisotopic Molecular Weight270.011878774
IUPAC Name2-amino-4-[(2-amino-2-carboxyethyl)selanyl]butanoic acid
Traditional Nameselenocystathionine
CAS Registry Number2196-58-9
SMILES
NC(CC[Se]CC(N)C(O)=O)C(O)=O
InChI Identifier
InChI=1S/C7H14N2O4Se/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)
InChI KeyZNWYDQPOUQRDLY-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acids
Alternative Parents
Substituents
  • Alpha-amino acid
  • Dicarboxylic acid or derivatives
  • Fatty acid
  • Amino acid
  • Carboxylic acid
  • Selenoether
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Primary amine
  • Organoselenium compound
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Organopnictogen compound
  • Organic oxygen compound
  • Carbonyl group
  • Amine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cytoplasm
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point58 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-4ALOGPS
logP-7.4ChemAxon
logS-0.49ALOGPS
pKa (Strongest Acidic)1.2ChemAxon
pKa (Strongest Basic)9.54ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area126.64 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity56.89 m³·mol⁻¹ChemAxon
Polarizability21.05 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
HMDB IDHMDB0006343
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023895
KNApSAcK IDNot Available
Chemspider ID88693
KEGG Compound IDC05699
BioCyc IDNot Available
BiGG ID46314
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound98223
PDB IDNot Available
ChEBI ID26630
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Cystathionine gamma-lyase
General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity).
Gene Name:
CTH
Uniprot ID:
Q58DW2
Molecular weight:
44406.0
Reactions
Selenocystathionine + Water → Selenocysteine + Ammonia + 2-Ketobutyric aciddetails
Enzyme Details
2. Cystathionine beta-synthase
General function:
Not Available
Specific function:
Not Available
Gene Name:
CBS
Uniprot ID:
F1MEW4
Molecular weight:
62867.0
Reactions
L-Serine + Selenohomocysteine → Selenocystathionine + Waterdetails