Showing metabocard for Thiamine pyrophosphate (BMDB0001372)

General function:

Nucleotide transport and metabolism

Specific function:

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity).

Gene Name:

NTPCR

Uniprot ID:

Q1LZ78

Molecular weight:

20682.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway.

Gene Name:

ILVBL

Uniprot ID:

A6QQT9

Molecular weight:

68110.0

General function:

Energy production and conversion

Specific function:

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Gene Name:

TKTL1

Uniprot ID:

Q2NL26

Molecular weight:

64966.0

General function:

Energy production and conversion

Specific function:

Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity).

Gene Name:

TKTL2

Uniprot ID:

Q2NKZ4

Molecular weight:

67501.0

General function:

Energy production and conversion

Specific function:

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Gene Name:

TKT

Uniprot ID:

Q6B855

Molecular weight:

67906.0

General function:

Energy production and conversion

Specific function:

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

Gene Name:

BCKDHA

Uniprot ID:

P11178

Molecular weight:

51678.0

Reactions

General function:

Energy production and conversion

Specific function:

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

Gene Name:

BCKDHB

Uniprot ID:

P21839

Molecular weight:

42935.0

Reactions

General function:

Energy production and conversion

Specific function:

2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.

Gene Name:

OGDH

Uniprot ID:

Q148N0

Molecular weight:

115808.0

General function:

Energy production and conversion

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Gene Name:

PDHA1

Uniprot ID:

A7MB35

Molecular weight:

43388.0

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity).

Gene Name:

TPK1

Uniprot ID:

Q5E9T4

Molecular weight:

27028.0

Reactions

General function:

Energy production and conversion

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Gene Name:

PDHB

Uniprot ID:

P11966

Molecular weight:

39126.0

General function:

Involved in adenylate cyclase activity

Specific function:

Hydrolase highly specific for thiamine triphosphate (ThTP).

Gene Name:

THTPA

Uniprot ID:

Q8MKF1

Molecular weight:

23983.0

Reactions

General function:

Involved in binding

Specific function:

Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.

Gene Name:

SLC25A19

Uniprot ID:

Q29RM1

Molecular weight:

35112.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

HACL1

Uniprot ID:

A5PJL6

Molecular weight:

63591.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

OGDH

Uniprot ID:

A8KC82

Molecular weight:

48383.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ILVBL

Uniprot ID:

B0JYQ9

Molecular weight:

68223.0