Showing metabocard for Tetrahydropteridine (BMDB0001216)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (1) Show 1 proteinXML
Record Information
Version1.0
Creation Date2016-09-30 22:42:41 UTC
Update Date2020-04-22 15:07:10 UTC
BMDB IDBMDB0001216
Secondary Accession Numbers
  • BMDB01216
Metabolite Identification
Common NameTetrahydropteridine
DescriptionTetrahydropteridine, also known as H4-biopterin or THP, belongs to the class of organic compounds known as pteridines and derivatives. These are polycyclic aromatic compounds containing a pteridine moiety, which consists of a pyrimidine fused to a pyrazine ring to form pyrimido(4,5-b)pyrazine. Tetrahydropteridine is a very strong basic compound (based on its pKa). Tetrahydropteridine exists in all living organisms, ranging from bacteria to humans.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
5,6,7,8-TetrahydropteridineKegg
5,6,7,8-Tetrahydro-pteridineHMDB
H4-BiopterinHMDB
THPHMDB
TetrahydropteridineChEBI
Chemical FormulaC6H8N4
Average Molecular Weight136.1545
Monoisotopic Molecular Weight136.074896276
IUPAC Name5,6,7,8-tetrahydropteridine
Traditional Name5,6,7,8-tetrahydropteridine
CAS Registry Number10593-78-9
SMILES
C1CNC2=C(N1)C=NC=N2
InChI Identifier
InChI=1S/C6H8N4/c1-2-9-6-5(8-1)3-7-4-10-6/h3-4,8H,1-2H2,(H,7,9,10)
InChI KeyIDAICLIJTRXNER-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as pteridines and derivatives. These are polycyclic aromatic compounds containing a pteridine moiety, which consists of a pyrimidine fused to a pyrazine ring to form pyrimido(4,5-b)pyrazine.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPteridines and derivatives
Sub ClassNot Available
Direct ParentPteridines and derivatives
Alternative Parents
Substituents
  • Pteridine
  • Secondary aliphatic/aromatic amine
  • Imidolactam
  • Pyrimidine
  • Heteroaromatic compound
  • Azacycle
  • Secondary amine
  • Organic nitrogen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cytoplasm
  • Mitochondria
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.29ALOGPS
logP-0.58ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)19.35ChemAxon
pKa (Strongest Basic)5.42ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area49.84 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity41.45 m³·mol⁻¹ChemAxon
Polarizability13.53 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Mitochondria
Biospecimen LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
HMDB IDHMDB0001216
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022495
KNApSAcK IDNot Available
Chemspider ID151
KEGG Compound IDC05650
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID6086
PubChem Compound156
PDB IDNot Available
ChEBI ID28889
References
Synthesis ReferenceTaylor, E. C., Jr.; Carbon, John A.; Garland, Robert B.; Hoff, Dale R.; Howell, Charles F.; Sherman, Wm. R. Recent developments in pteridine synthesis. Ciba Foundation Symposium, Chem. and Biol. Pteridines (1954), 104-20.
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Dihydropteridine reductase
General function:
Lipid transport and metabolism
Specific function:
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
Gene Name:
QDPR
Uniprot ID:
Q3T0Z7
Molecular weight:
25504.0