Showing metabocard for Citrulline (BMDB0000904)

General function:

Inorganic ion transport and metabolism

Specific function:

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Gene Name:

NOS3

Uniprot ID:

P29473

Molecular weight:

133287.0

General function:

Inorganic ion transport and metabolism

Specific function:

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.

Gene Name:

NOS2

Uniprot ID:

Q27995

Molecular weight:

131208.0

General function:

Nucleotide transport and metabolism

Specific function:

One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.

Gene Name:

ASS1

Uniprot ID:

P14568

Molecular weight:

46417.0

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General function:

Amino acid transport and metabolism

Specific function:

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity).

Gene Name:

DDAH2

Uniprot ID:

Q3SX44

Molecular weight:

29780.0

General function:

Amino acid transport and metabolism

Specific function:

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Gene Name:

DDAH1

Uniprot ID:

P56965

Molecular weight:

31289.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

OTC

Uniprot ID:

Q9N1U7

Molecular weight:

39842.0

Reactions