Showing metabocard for Uridine diphosphate-N-acetylglucosamine (BMDB0000290)

General function:

Involved in alpha-1,3-mannosylglycoprotein 2-beta-N-ace

Specific function:

Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.

Gene Name:

POMGNT1

Uniprot ID:

Q5EAB6

Molecular weight:

75077.0

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.

Gene Name:

DPAGT1

Uniprot ID:

Q5EA65

Molecular weight:

46045.0

General function:

Involved in glucuronosyl-N-acetylglucosaminyl-proteogly

Specific function:

Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan.

Gene Name:

EXT2

Uniprot ID:

O77783

Molecular weight:

81887.0

General function:

Involved in glucuronosyl-N-acetylglucosaminyl-proteogly

Specific function:

Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).

Gene Name:

EXT1

Uniprot ID:

A5D7I4

Molecular weight:

86299.0

General function:

Involved in alpha-1,3-mannosylglycoprotein 4-beta-N-ace

Specific function:

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.

Gene Name:

MGAT4A

Uniprot ID:

O77836

Molecular weight:

61618.0

General function:

Involved in phosphatidylinositol N-acetylglucosaminyltr

Specific function:

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Gene Name:

PIGH

Uniprot ID:

Q32L89

Molecular weight:

21006.0

General function:

Involved in phosphatidylinositol N-acetylglucosaminyltr

Specific function:

Involved in GPI anchor biosynthesis. Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Gene Name:

PIGC

Uniprot ID:

Q3ZBX1

Molecular weight:

33628.0

General function:

Involved in beta-1,3-galactosyl-O-glycosyl-glycoprotein

Specific function:

Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.

Gene Name:

GCNT1

Uniprot ID:

Q92180

Molecular weight:

49734.0

General function:

Involved in beta-1,3-galactosyl-O-glycosyl-glycoprotein

Specific function:

Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.

Gene Name:

GCNT3

Uniprot ID:

Q7YQE1

Molecular weight:

50953.0

General function:

Involved in N-acetyllactosaminide beta-1,3-N-acetylgluc

Specific function:

Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1).

Gene Name:

B4GAT1

Uniprot ID:

Q5EA01

Molecular weight:

47231.0

General function:

Carbohydrate transport and metabolism

Specific function:

Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides (By similarity).

Gene Name:

SLC35A3

Uniprot ID:

Q6YC49

Molecular weight:

36067.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

UAP1

Uniprot ID:

F1MJP7

Molecular weight:

58623.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

GNE

Uniprot ID:

F1MIL9

Molecular weight:

79390.0

Reactions