Showing metabocard for Oxalacetic acid (BMDB0000223)

General function:

Energy production and conversion

Specific function:

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.

Gene Name:

ACLY

Uniprot ID:

Q32PF2

Molecular weight:

119789.0

Reactions

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

CS

Uniprot ID:

Q29RK1

Molecular weight:

51773.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity).

Gene Name:

GOT1

Uniprot ID:

P33097

Molecular weight:

46399.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity).

Gene Name:

GOT2

Uniprot ID:

P12344

Molecular weight:

47514.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

GOT1L1

Uniprot ID:

Q2T9S8

Molecular weight:

45918.0

General function:

Involved in ATP binding

Specific function:

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity).

Gene Name:

PC

Uniprot ID:

Q29RK2

Molecular weight:

129698.0

Reactions

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

MDH2

Uniprot ID:

Q32LG3

Molecular weight:

35668.0

General function:

Energy production and conversion

Specific function:

Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate.

Gene Name:

PCK1

Uniprot ID:

Q8HYZ4

Molecular weight:

69353.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

DDO

Uniprot ID:

P31228

Molecular weight:

37660.0

Reactions

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

MDH2

Uniprot ID:

Q58DR9

Molecular weight:

30024.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

MDH1

Uniprot ID:

Q3T145

Molecular weight:

36438.0

Reactions

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

MDH2

Uniprot ID:

Q0QF29

Molecular weight:

29951.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

IL4I1

Uniprot ID:

F1N191

Molecular weight:

64479.0

Reactions