Showing metabocard for Norepinephrine (BMDB0000216)

General function:

Involved in phenylethanolamine N-methyltransferase acti

Specific function:

Converts noradrenaline to adrenaline.

Gene Name:

PNMT

Uniprot ID:

P10938

Molecular weight:

30918.0

Reactions

General function:

Involved in catechol O-methyltransferase activity

Specific function:

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity).

Gene Name:

COMT

Uniprot ID:

A7MBI7

Molecular weight:

30485.0

Reactions

General function:

Involved in copper ion binding

Specific function:

Conversion of dopamine to noradrenaline.

Gene Name:

DBH

Uniprot ID:

P15101

Molecular weight:

68141.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Gene Name:

MAOA

Uniprot ID:

P21398

Molecular weight:

59758.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

Gene Name:

SLC18A2

Uniprot ID:

Q27963

Molecular weight:

55756.0

General function:

Involved in neurotransmitter:sodium symporter activity

Specific function:

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Gene Name:

SLC6A2

Uniprot ID:

P51143

Molecular weight:

68900.0

General function:

Involved in beta2-adrenergic receptor activity

Specific function:

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).

Gene Name:

ADRB2

Uniprot ID:

Q28044

Molecular weight:

47136.0

General function:

Not Available

Specific function:

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).

Gene Name:

ADRB1

Uniprot ID:

Q9TT96

Molecular weight:

50137.0