Showing metabocard for Dopamine (BMDB0000073)

General function:

Involved in catechol O-methyltransferase activity

Specific function:

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity).

Gene Name:

COMT

Uniprot ID:

A7MBI7

Molecular weight:

30485.0

Reactions

General function:

Involved in copper ion binding

Specific function:

Conversion of dopamine to noradrenaline.

Gene Name:

DBH

Uniprot ID:

P15101

Molecular weight:

68141.0

Reactions

General function:

Involved in copper ion binding

Specific function:

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.

Gene Name:

TYR

Uniprot ID:

Q8MIU0

Molecular weight:

60304.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Gene Name:

MAOA

Uniprot ID:

P21398

Molecular weight:

59758.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Gene Name:

DDC

Uniprot ID:

P27718

Molecular weight:

54294.0

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

Gene Name:

SLC18A2

Uniprot ID:

Q27963

Molecular weight:

55756.0

General function:

Involved in dopamine:sodium symporter activity

Specific function:

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

Gene Name:

SLC6A3

Uniprot ID:

P27922

Molecular weight:

75691.0

General function:

Not Available

Specific function:

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

Gene Name:

DRD2

Uniprot ID:

P20288

Molecular weight:

50672.0

General function:

Involved in dopamine receptor binding

Specific function:

Not Available

Gene Name:

NSG1

Uniprot ID:

Q08DZ1

Molecular weight:

20968.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

D5 dopamine receptor

Uniprot ID:

Q28919

Molecular weight:

7597.0

General function:

Involved in GTP binding

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q9TSC8

Molecular weight:

10097.0

General function:

Involved in dopamine receptor binding

Specific function:

Not Available

Gene Name:

CALY

Uniprot ID:

Q0VCJ9

Molecular weight:

24662.0

General function:

Involved in dopamine receptor activity

Specific function:

Not Available

Gene Name:

DRD4

Uniprot ID:

Q8WNT0

Molecular weight:

11933.0

General function:

Involved in dopamine receptor binding

Specific function:

Not Available

Gene Name:

NSG2

Uniprot ID:

Q0VCZ0

Molecular weight:

19028.0

General function:

Not Available

Specific function:

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Gene Name:

DRD5

Uniprot ID:

Q95137

Molecular weight:

19589.0

General function:

Involved in dopamine receptor activity

Specific function:

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Gene Name:

DRD1

Uniprot ID:

Q95136

Molecular weight:

49317.0